The antioxidants in question here are NOT from the natural sources but from the ones found in artificial supplements which millions of people consume on a daily basis.
Vitamins A, C and E and beta-carotene constitute the antioxidant class of vitamins. Latest research has shown that an EXCESS of synthetic antioxidants SUPPLIED THROUGH vitamin supplements causes increased cancer growth. This raises alarm because nearly ALL low-grade supplements do contain synthetic antioxidant amounts in excess of the body's daily absorption limit. If you notice the percent daily value label on your supplement bottle, you will find the components to be in heavy excess.
Here are some facts:
A highly reputed study published in Science Translational Medicine (Jan. 2014) concluded that a diet supplemented with vitamin E and N-acetyl cysteine (a modified amino acid supplement and a drug) significantly increased rate of tumor growth, led to aggressive tumors and halved the survival rate in mice. These work by inactivating a specific gene (p53) which controls cancer growth in a normal person. Once p53 is inactivated, the antioxidant effect simply does not work. The scientists suggested that those with a high risk of developing cancers should completely abstain from antioxidant supplementation (that is any vitamin supplement).Another research article published in Mayo Clinic Proceedings tested the effect of antioxidant use and primary cancer incidence. They concluded that beta-carotene supplements increased the cancer occurrence as well as mortality in smokers.
The National Cancer Institute (NCI) has conducted several prolonged human clinical trials to study the effects of antioxidant supplements. None of these trials reported any beneficial effects regarding cancer prevention. The NCI concluded, "Research in humans has not demonstrated convincingly that taking antioxidant supplements can help reduce the risk of developing or dying from cancer, and some studies have even shown an increased risk of some cancers."
This conclusion was based upon:
Clinical Trial 1 (5- to 8-year study) -- Result: Beta-carotene supplements led to increased lung cancer risk. Alpha-tocopherol showed no good/bad effect.
Clinical Trial 2 (8-year study) -- Result: Vitamin A and beta-carotene increased lung cancer and death, due to which the trial was ended two years ahead of the initial schedule. Adverse effects persisted up to six years after supplementation was stopped.
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